BOOK Prolis LIS DEMO
Professional Laboratory Information System Software
Prolis LIS Software | One Complete Platform for Order to Payment
Prolis is a laboratory information system (LIS) built for modern diagnostic and clinical laboratories. As a complete LIS software platform, it connects specimen orders, analyzer results and EMR integrations, and billing in one seamless system. From accession to final payment, every step is automated, accurate, and audit-ready for CLIA-certified labs.
CLIA & HIPAA Compliant
Complete Accession-to-Billing Workflow
Seamless Analyzer Integration via Prolis Bridge
Cloud-Based or On-Premise Deployment
Trusted & Certified Laboratory Information System
CLIA Certified
HIPAA Compliant
HL7 / FHIR Ready
837/835 EDI Billing
EMR Integrated
Common Lab Software Problem
Is Your Laboratory Still Running Without a Unified LIS?
Laboratory owners and directors depend on a modern laboratory information system to keep operations running smoothly. Without a unified LIS in place, labs lose time to manual entry, disconnected billing, compliance risk, and operational bottlenecks. A well-built system removes these obstacles.
- Fragmented modules that force manual order entry and invite transcription errors
- Analyzer results that don't auto-upload into your main platform
- Separate billing systems that slow down the revenue cycle
- QC reporting handled manually, disconnected from the rest of your operation
- Providers waiting days for results by fax instead of getting them electronically
- No real-time visibility into turnaround time, AR metrics, or operational performance
Prolis LIS Solution
Best LIS Software for Total Lab Control
Prolis isn't just another piece of lab software it's a complete platform engineered to eliminate every bottleneck between your first specimen order and your final payment collected.
Built since 2009 by American Soft Solutions Corp., Prolis pairs a powerful core system with Prolis Bridge, an integration hub that connects the platform to EMRs, lab analyzers, provider portals, and billing clearinghouses.
Tests are configured at the analyte level, not the module level, so every clinical specialty chemistry, toxicology, molecular, pathology, and more runs natively, without expensive add-ons or fragmented pricing.
Best LIS Software for Clinical Laboratories — Prolis is built for lab owners, directors, and managers who need speed, accuracy, and end-to-end compliance in a single integrated platform.
Lab Ecosystem Integration
A Complete Laboratory Information System Ecosystem
Prolis Bridge sits at the core of the platform, enabling seamless, bi-directional communication between your internal lab operations and the outside healthcare networks you work with.
EMRs & EHRs Connected
HL7 Integration
Provider Portal
Web Orders & Secure Results
Prolis
Bridge
Integration HubLab Analyzers Connected
Bi-directional Interfaces
Core Platform
Centralized Lab Operations
Complete LIS Workflow
Prolis LIS Lifecycle: Precision From Order to Payment
Every phase of your lab's workflow pre-analytical, analytical, post-analytical, and revenue is managed inside one intelligent LIS software platform.
1
Pre-Analytical Phase
Order Accession
Orders flow in from EMRs via HL7 integration or the Provider Portal module. Each specimen receives a unique accession ID and barcode label and is routed automatically, without manual intervention.
2
Analytical Phase
Analyzer Results
Prolis connects directly to your lab analyzers through Prolis Bridge. Results are captured in real time, uploaded automatically, checked against QC rules, and reviewed with built-in delta checks before release.
3
Post-Analytical Phase
Report Generation
Verified results compile into fully customizable, audit-ready clinical and operational reports, formatted to your specifications and delivered through the EMR or the secure Provider Portal.
4
Revenue Cycle
Billing Management
The Billing Scrubber module prepares clean claims automatically. The platform generates 837 files, routes them through the clearinghouse, processes ERA 835 remittances, and posts payments all without leaving the system.
LIS Software Core Modules
Four Pillars of the Laboratory Information System
Prolis LIS software comprises four primary modules designed to handle every critical part of the modern lab workflow. Use the tabs below to explore each core module.
Core Software Module
Highly Configurable
Configures tests at the analyte level, supporting chemistry, toxicology, microbiology, pathology, and molecular testing natively in one platform.
Order Management
Streamlines accessioning and queue management to prevent bottlenecks and keep specimens moving efficiently.
Resulting Workflow
Automated workflows for result verification, release, and delta checks maintain quality and compliance at every step.
QC Management & Reporting
Built-in Levey-Jennings charts, audit trails, and customizable reporting handle quality control and compliance documentation.
Prolis Bridge Integration Module
Analyzer Interfacing
Robust, bi-directional communication with a broad library of lab instruments makes analyzer integration straightforward.
EMR Integration
Seamless data exchange over HL7/FHIR standards connects the platform to external healthcare networks and major EHR systems.
RCM & Clearing House Integration
A built-in billing scrubber, claims generation, ERA processing, and eligibility checks manage the full revenue cycle.
State Reporting
Automated compliance and public health data transmission keep regulatory reporting accurate and on time.
Provider Portal Module
Web Orders
A clean, intuitive order-entry screen lets physicians and clinics submit lab tests electronically, directly into the LIS.
Results Access
Real-time access to patient results, with secure PDF generation and downloads.
Provider Communication
Instant alerts, panic value management, and direct messaging keep providers informed and improve clinical workflows.
White-Labeled Portal
Branded portal options reflect your lab's identity and strengthen client relationships.
Patient Portal Module
Secure Access
Strict HIPAA-compliant login protocols protect patient data and privacy.
Result Notifications
Automated alerts go out to patients as soon as their results are finalized.
Patient Engagement
Patients get direct control over their health data, which reduces inbound calls to the lab and improves satisfaction.
Complete LIS Software Features
Everything a Modern Laboratory Needs — Built Into One LIS
Most vendors sell fragmented laboratory information systems and charge extra for every add-on. Prolis LIS software delivers a complete feature set across your entire lab operation, right out of the box.
Order Management & Accessioning
Streamline order intake from EMRs, the Provider Portal, or manual entry. Automated barcode generation, department routing, and accession queues eliminate pre-analytical errors at the source.
Analyzer Interface & QC
Bidirectional analyzer connectivity through Prolis Bridge enables real-time result upload, automated QC checks, delta checks, and result verification nothing gets released without meeting your quality standards.
Clinical & Operational Reporting
Generate clinical reports, Levey-Jennings QC charts, TAT monitoring, audit trails, and operational dashboards, all formatted to your specifications and auto-delivered. Built for CLIA compliance from day one.
Integrated Lab Billing & Revenue Cycle
Manage the complete revenue cycle eligibility verification, 837 claim generation, ERA 835 processing, denial management, payment posting, AR tracking, and invoicing in one place.
Prolis Bridge Integration Hub
Prolis Bridge is the connective layer linking the core platform to EMRs, lab analyzers, clearinghouses, state reporting systems, and RCM platforms through a single, secure integration point.
Provider & Patient Portals
Give providers a branded, secure web portal for submitting orders and reviewing results. Give patients a portal with secure access, email notifications, downloadable results, and direct engagement tools.
Multi-Specialty Laboratory Software
Supporting Every Clinical Specialty With One LIS
Prolis LIS software isn't siloed by department. Because tests are configured at the analyte level, this single laboratory information system handles your entire test menu from routine chemistry to advanced molecular diagnostics.
Chemistry
Hematology
Microbiology
Toxicology
Molecular
Immunology
Coagulation
Autoimmune
Solutions Served by Prolis LIS
Professional LIS Software Built for Every Type of Laboratory
Whether you run a solo physician office lab or a multi-site reference network, Prolis LIS scales to your operations without replacing your workflow it strengthens it with a complete laboratory information system.
Physician Office Labs
A lightweight yet powerful system for in-office testing. Fast setup, simple workflows, and direct EMR connectivity for busy clinical settings.
Reference Laboratories
High-volume, multi-client labs rely on Prolis for scalable accession management, robust QC, multi-provider portals, and automated billing.
Clinical Laboratories
Hospital-affiliated and independent labs get one unified system connecting every department, from chemistry to microbiology.
Toxicology Laboratories
Purpose-built workflows for drug screening, confirmatory testing, and chain-of-custody documentation. Fully compliant and deeply configurable for pain management labs.
Pathology Laboratories
Prolis supports pathology-specific workflows including specimen management, surgical pathology reporting, and result delivery to providers and patients.
Molecular Laboratories
From PCR panels to NGS workflows and pharmacogenetics, Prolis handles molecular testing with the precision and flexibility complex genetic diagnostics demand.
Role-Based LIS Business Impact
See the Measurable Impact of LIS Software, By Role
Different stakeholders care about different things when adopting a new laboratory information system. Select a role below to see the operational improvements and business value it delivers.
Lab Owners & Leadership
Maximize ROI and revenue cycle performance. Reduce denied claims and scale operations without hidden costs.
Lab Directors & Technical Staff
Stay ahead of compliance. Strict QC, audit trails, and rules-based workflows support CLIA/HIPAA requirements.
Lab Managers & Operations
Automate the busywork. Eliminate manual entry, enable remote accessioning, and automate delta checks.
Representative impact on the revenue cycle with Prolis (Owners view)
Typical operational metrics comparing legacy disconnected systems to an integrated Prolis environment.
Comprehensive Prolis LIS Feature Library
Search. Filter. Explore LIS Features.
Prolis LIS software includes dozens of specific operational tools. Search by feature name or filter by category to see the full breadth of this laboratory information system.
Search Prolis LIS Software Capabilities
No features found matching your search criteria.
Reviews From Lab Leaders
Trusted by Lab Directors, Managers & IT Administrators
Laboratory and IT leaders across the country rely on Prolis to run their day-to-day operations.
★★★★★
"We had complex requirements for integrating our existing lab equipment. Prolis didn't just hand us software they found solutions to get everything connected. Managing everything from one platform is unmatched."
Eric Martin T.IT Administrator | Hospital & Healthcare
★★★★★
"The transition from our old system was exceptionally smooth. Unlike other vendors who cash the check and leave you with a manual, the Prolis team was with us daily during implementation. Even our clients compliment how simple the web portal is."
Joanna P.Laboratory Technical Director
★★★★★
"Capturing billable lab samples is a flawless feature. The integrated billing and collection functions have significantly reduced our manual errors and improved turnaround time on insurance claims."
Marci R.Operations Manager
Why Choose Prolis LIS Software
What Sets Prolis Apart From Other Laboratory Information Systems?
The LIS market is full of outdated, modular systems that charge per feature and require separate vendors for billing, reporting, and integration. Prolis was built from the ground up to work differently.
Analyte-Level Configuration — Not Module-Level
Most vendors sell a separate module for every specialty. Prolis configures each test at the analyte level, so one complete system runs chemistry, toxicology, molecular, and more, without extra cost or complexity.
Native Automation at Every Step
Auto-accession, auto-upload from analyzers, auto-generated reports, and automated claims remove the manual steps that slow labs down and cause costly errors.
Built-In Compliance & Audit Readiness
CLIA and HIPAA compliance aren't bolted on. Every workflow is designed with audit trails, QC documentation, and result integrity built into its core.
White-Glove Implementation & Support
Unlike competitors who hand you a manual and disappear, Prolis provides dedicated implementation support, personalized training, and responsive ongoing assistance.
LIS Software FAQs
Have questions about implementing a laboratory information system (LIS)? Here are the answers that matter most to lab owners, directors, and managers evaluating the best LIS software for their lab.
What is a laboratory information system (LIS) and how does it work?
A laboratory information system is a healthcare software solution that manages the processing, storage, and reporting of patient data related to lab testing. Prolis handles everything from order intake and specimen accession to result reporting and revenue cycle management, all within one integrated platform.
What makes Prolis the best choice compared to other systems?
Prolis configures tests at the analyte level rather than by module, so you get full specialty support without paying for fragmented add-ons. Billing, EMR integration, analyzer connectivity, provider portals, and QC management are all included in one platform that's been developed and supported since 2009.
Which lab types does Prolis support?
Prolis is designed for clinical, reference, toxicology, pathology, molecular, and physician office labs. Whether you're a solo POL or a multi-site reference network, it scales to your volume, specialty mix, and client structure.
Does Prolis integrate with EMR and EHR systems?
Yes. Prolis connects to major EMR and EHR platforms through Prolis Bridge, supporting bidirectional HL7/FHIR messaging. Orders come in from EMRs automatically, and verified results go back out — eliminating manual entry on both ends.
Is Prolis CLIA and HIPAA compliant?
Yes. Prolis is built for CLIA-certified diagnostic labs and maintains HIPAA compliance throughout every workflow, including audit trails, access controls, secure result delivery, and data encryption.
How long does implementation take?
Timelines vary based on lab size, integrations, and test menu complexity. Prolis provides a dedicated implementation team to guide you through setup, configuration, training, and go-live, with ongoing support available after launch.
Ready to Modernize Your Laboratory With a Complete LIS?
Join diagnostic laboratories across the country that trust Prolis to power daily operations, from first specimen accession to final payment collected. Book a personalized demo and see the difference.
15+Years of Innovation
8Clinical Specialties
1Unified LIS Software Solution
24/7Technical Support Available
Prolis Laboratory Information System (LIS) software is intended for use in CLIA-certified diagnostic laboratory testing facilities within the United States (US) market.