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Laboratory Information System (LIS) Software
The Only LIS System Your Lab Will Ever Need
Prolis is a professional LIS software system built for modern labs connecting orders, analyzers, EMRs, and billing in one seamlessly integrated platform. From accession to final invoice, every step is automated, accurate, and audit-ready.
CLIA & HIPAA Compliant
Accession to Billing in One Platform
Seamless EMR & Analyzer Integration
Cloud-Based or On-Premise
Trusted & Certified
CLIA Certified
HIPAA Compliant
HL7 / FHIR Ready
837/835 EDI Billing
EMR Integrated
The Lab Management Problem
Is Your Lab Still Losing Time & Revenue to Disconnected Systems?
Lab owners and directors face a daily battle against fragmented software, manual data entry, delayed billing, and compliance risks. Without a unified LIS software system, your lab pays the price in errors, in overhead, and in lost revenue.
- Manual order entry creating transcription errors and rework
- Analyzer results that don't auto-upload into your LIS
- Billing delays caused by disconnected revenue cycle tools
- QC reporting done manually, outside the core system
- Providers waiting days for results via fax or email
- No real-time visibility into TAT, AR, or operational metrics
The Prolis LIS Solution
One LIS Software System. Total Lab Control.
Prolis is not just another lab software. It is a complete, end-to-end Laboratory Information System (LIS) engineered to eliminate every bottleneck between your first specimen and your last dollar collected.
Built since 2009 by American Soft Solutions Corp., Prolis combines your core LIS software with the Prolis Bridge a powerful integration hub that connects your lab to EMRs, lab analyzers, provider portals, and billing clearinghouses, all from one platform.
💡 Prolis configures tests at the analyte level not the module level supporting every clinical specialty without fragmented systems or costly add-ons.
Prolis LIS Software — Designed for Lab Owners, Lab Directors & Lab Managers who demand speed, accuracy, and compliance in one place.
The Connectivity Hub
More Than Software. A Complete Lab Ecosystem.
Prolis utilizes a central integration hub ("Prolis Bridge") to facilitate seamless bi-directional communication between your internal laboratory systems and the outside world.
EMRs & EHRs
HL7 Integration
Provider Portal
Web Orders & Results
Prolis
Bridge
Integration Hub
Lab Analyzers
Bi-directional
LIS Software
Core Operations
End-to-End Lab Workflow
The Prolis LIS Lifecycle:
The Prolis LIS Lifecycle:
Precision From Order to Payment
Every phase of your laboratory workflow pre-analytical, analytical, post-analytical, and revenue is managed seamlessly inside one intelligent LIS system.
1
Pre-Analytical
Accession
Orders flow in from EMRs or the Provider Portal. Each specimen receives a unique accession ID, barcode label, and is routed to the right department automatically, without manual intervention.
2
Analytical
Analysis
Prolis connects directly to your lab analyzers via Prolis Bridge. Results are captured in real time, auto-uploaded, verified against QC rules, and reviewed with built-in delta checks before release.
3
Post-Analytical
Reporting
Verified results compile into fully customizable, audit-ready clinical and operational reports automatically formatted to your client specifications and delivered via EMR or secure Provider Portal.
4
Revenue Cycle
Billing
The Billing Scrubber prepares clean claims. Prolis generates 837 files, routes through the clearing house, processes ERA 835 remittance, and posts payments closing the revenue loop without leaving the system.
Core Platform Modules
Four Pillars. One Unified System.
The Prolis platform is divided into four primary modules designed to handle specific aspects of the laboratory lifecycle. Use the interactive tabs below to explore each one.
Core LIS Software
Highly Configurable
Configures tests at the analyte level, supporting chemistry, toxicology, microbiology, pathology, and molecular testing natively.
Order Management
Streamline accessioning and queue management to prevent operational bottlenecks.
Resulting Workflow
Automated workflows for result verification, release, and delta checks.
QC Management & Reporting
Built-in Levy-Jennings charts, audit trails, and customizable reporting engines.
Prolis Bridge (Integration)
Analyzer Interfacing
Robust, bi-directional communication with a vast library of lab instruments.
EMR Integration
Seamless data exchange utilizing HL7 standards to connect with external healthcare networks.
RCM Integration & Clearing House
Built-in billing scrubber, claims generation, ERA processing, and eligibility checks.
State Reporting
Automated compliance and public health data transmission.
Provider Portal
Web Orders
Clean, intuitive order entry for physicians and clinics to submit tests electronically.
View & Download Results
Real-time access to patient results with secure PDF generation and downloading.
Provider Communication
Instant alerts, panic value management, and direct communication channels.
Branded Experience
White-labeled portal options that reflect your laboratory's unique identity.
Patient Portal
Secure Access
Strictly HIPAA-compliant login protocols ensuring patient data privacy and peace of mind.
Email Notifications
Automated system alerts sent directly to patients when their test results are finalized.
Patient Engagement
Empower patients to take control of their health data, reducing inbound calls to the lab and improving patient satisfaction.
Core LIS Software Features
Everything a Modern Lab Needs Built In.
Unlike modular LIS solutions that charge for every add-on, Prolis delivers a complete feature set across your entire lab operation right out of the box.
Order Management & Accession
Streamline order intake from EMRs, Provider Portal, or manual entry. Automate barcode label generation, department routing, accession queues, and standing orders eliminating pre-analytical errors at the source.
Analyzer Interface & QC Management
Bidirectional analyzer connectivity through Prolis Bridge enables real-time result upload, automated QC checks, delta checks, and result verification so nothing gets released without passing your quality standards.
Clinical & Operational Reporting
Generate clinical reports, Levey-Jennings QC charts, TAT monitoring, audit trails, and operational dashboards all formatted to your specs and auto-delivered. Built for CLIA compliance from day one.
Integrated Lab Billing & RCM
Prolis manages the complete revenue cycle from eligibility verification and 837 claim generation to ERA 835 processing, denial management, payment posting, AR tracking, and invoicing.
Prolis Bridge Integration Hub
The Prolis Bridge is the connective tissue of your lab ecosystem linking your LIS software to EMRs, lab analyzers, clearing houses, state reporting systems, and RCM platforms through a single, secure integration layer.
Provider Portal & Patient Portal
Give providers a branded, secure web portal to submit orders and review results. Empower patients with a patient-facing portal featuring secure access, email notifications, downloadable results, and direct engagement tools.
Multi-Specialty LIS System
Supporting Every Clinical Specialty In One LIS Platform
Prolis is not siloed by department. Because it configures tests at the analyte level, a single LIS software system runs your entire test menu from routine chemistry to advanced molecular diagnostics.
Chemistry
Hematology
Microbiology
Toxicology
Molecular
Immunology
Coagulation
Autoimmune
Prolis Bridge Integration Hub
More Than LIS Software
More Than LIS Software
A Complete Lab Ecosystem
Prolis Bridge is the integration engine at the heart of your LIS system, linking every layer of your lab to the external world from analyzer floors to insurance clearing houses.
EMR / EHR Integration
Bidirectional HL7/FHIR messaging with major EHR platforms. Orders come in, results go out automatically.
Lab Analyzer Connectivity
Direct interface to clinical chemistry, hematology, molecular, and immunology analyzers from leading manufacturers.
Provider Portal
A branded, web-based ordering portal for your referring providers with real-time result access and communication tools.
Clearing House & RCM
Automated 837 claim submission, ERA 835 processing, eligibility checks, and RCM integration all inside Prolis.
Prolis also supports state reporting, clearing house connections, and custom third-party integrations through its open interfacing architecture.
Explore All Integrations →
Industries Served
LIS Software Built for Every Type of Lab
Whether you run a solo physician office lab or a multi-site reference laboratory, Prolis scales to your needs without replacing your workflow it enhances it.
🩺 Physician Office Labs (POL)
A lightweight yet powerful LIS system for in-office testing. Fast setup, simple workflows, and direct EMR connectivity for busy clinical settings.
🏢 Reference Laboratories
High-volume, multi-client reference labs rely on Prolis for scalable accession management, robust QC, multi-provider portals, and automated billing at scale.
🏥 Clinical Laboratories
Hospital-affiliated and independent clinical labs gain a unified LIS software system connecting every department from chemistry to microbiology in one platform.
🧪 Toxicology Laboratories
Purpose-built workflows for drug screening, confirmatory testing, and chain-of-custody documentation. Fully compliant and deeply configurable for pain management labs.
🔬 Pathology Laboratories
Prolis supports pathology-specific workflows including specimen management, surgical pathology reporting, and result delivery to ordering providers and patients.
🧬 Molecular Laboratories
From PCR panels to NGS workflows and pharmacogenetics, Prolis handles molecular testing with the precision and flexibility complex genetic diagnostics demand.
Role-Based Business Impact
See the Numbers. By Role.
Different lab stakeholders have different priorities. Select a role below to see the operational improvements experienced after implementing Prolis.
Lab Owners 💼
Maximize ROI & Revenue Cycle. Reduce denied claims and scale without hidden costs.
Lab Directors 🛡️
Ensure Compliance. Strict QC, audit trails, and rules-based workflows for CLIA/HIPAA.
Lab Managers ⚙️
Automate Workflows. Eliminate manual entry, remote accessioning, and automate delta checks.
Representative Impact on Revenue Cycle (Owners)
Typical operational metrics: disconnected systems vs. integrated Prolis environment.
Comprehensive Feature Library
Search. Filter. Explore.
Prolis encompasses dozens of specific operational tools. Search by feature name or filter by category to understand the true breadth of the system.
Search LIS Capabilities
No features found matching your criteria.
What Lab Leaders Are Saying
Trusted by Lab Directors, Managers & IT Administrators
★★★★★
"We had complex requirements for integrating our existing medical machines. Prolis didn't just provide software they found solutions to get everything connected. The ability to manage everything from within one LIS system is unmatched."
Eric Martin T.
IT Administrator | Hospital & Healthcare
★★★★★
"The transition from our old LIMS to Prolis was exceptionally smooth. Unlike other companies that cash the check and leave you with a manual, the Prolis support team was with us daily. Even our clients compliment how simple the web portal is."
Joanna P.
Laboratory Technical Director
★★★★★
"Capturing billable lab samples is a flawless feature in Prolis. The integrated billing and collection functions have significantly reduced our manual errors and improved our turnaround time for insurance claims."
Marci R.
Operations Manager
Why Choose Prolis LIS
What Sets Prolis Apart From Every Other LIS Software?
The LIS market is full of outdated, modular systems that charge per feature and require separate vendors for billing, reporting, and integration. Prolis was engineered from the ground up to be different.
🔧 Analyte-Level Configuration, Not Module-Level
Most LIS vendors sell a separate module for each specialty. Prolis configures every test at the analyte level meaning one system runs Chemistry, Toxicology, Molecular, and more without extra cost or complexity.
⚡ Native Automation at Every Step
Auto-accession, auto-upload from analyzers, auto-generated reports, and automated claims Prolis removes the manual steps that slow labs down and cause costly errors.
🔒 Built-In Compliance & Audit Readiness
CLIA and HIPAA compliance is not a bolt-on. Every workflow in Prolis is designed with audit trails, QC documentation, and result integrity built into the core of the LIS software system.
🤝 White-Glove Implementation & Ongoing Support
Unlike competitors who hand you a manual, Prolis provides dedicated implementation support, personalized training, and responsive ongoing assistance so your team is never left behind.
Frequently Asked Questions
Everything You Need to Know About Prolis LIS Software
Have questions about implementing a Laboratory Information System? Here are the answers that matter most to lab owners, directors, and managers evaluating LIS software.
What is a Laboratory Information System (LIS)?
A Laboratory Information System (LIS) is a healthcare software solution that manages the processing, storage, and reporting of patient data related to laboratory testing. A modern LIS system handles everything from order intake and specimen accession to result reporting and revenue cycle management all within one integrated platform.
What makes Prolis different from other LIS software?
Prolis is a complete LIS software system that configures tests at the analyte level not by module meaning you get full multi-specialty support without paying for fragmented add-ons. It includes built-in billing, EMR integration, analyzer connectivity, provider portals, and QC management in one platform developed and supported since 2009.
Which lab types does Prolis LIS support?
Prolis is designed for clinical, reference, toxicology, pathology, molecular, and physician office laboratories. Whether you are a solo POL or a multi-site reference lab, Prolis scales to your volume, specialty mix, and client structure.
Does Prolis LIS integrate with EMR systems?
Yes. Prolis connects to major EMR and EHR platforms through its Prolis Bridge integration hub, supporting bidirectional HL7/FHIR messaging. Orders come in from EMRs automatically, and verified results are delivered back eliminating manual data entry at both ends.
Is Prolis LIS CLIA and HIPAA compliant?
Absolutely. Prolis is designed for CLIA-certified diagnostic laboratories and maintains HIPAA compliance throughout all workflows including audit trails, access controls, secure result delivery, and data encryption standards.
How long does it take to implement Prolis LIS?
Implementation timelines vary based on lab size, integrations, and test menu complexity. Prolis provides a dedicated implementation team that works with you through setup, configuration, training, and go-live with ongoing support available post-launch. Contact us for a customized implementation plan.
Ready to Modernize Your Lab with the Right LIS System?
Join labs across the country that trust Prolis to power their daily operations from first accession to final payment. Book your personalized demo and see the difference a purpose-built LIS software system makes.
15+Years in LIS Development
8Clinical Specialties
1Unified LIS Platform
24/7Technical Support Available
This LIS system is intended for use in CLIA-certified diagnostic laboratory testing facilities within the United States market.