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Professional Laboratory Information System (LIS) Software
Prolis LIS Software | One Complete Platform for Order to Payment
Prolis is the best LIS software system built for modern diagnostic and clinical laboratories, connecting specimen orders, analyzer results, EMR integrations, and billing in one seamlessly integrated laboratory information system. From accession to final payment, every step is automated, accurate, and audit-ready for CLIA-certified labs.
CLIA & HIPAA Compliant LIS
Complete Accession to Billing in One LIS System
Seamless Analyzer Integration via LIS Bridge
Cloud-Based or On-Premise LIS Deployment
Trusted & Certified Laboratory Information System
CLIA Certified LIS
HIPAA Compliant LIS
HL7 / FHIR Ready
837/835 EDI Billing
EMR Integrated LIS
Common Lab Software Problem
Is Your Laboratory Still Using Disconnected LIS Software?
Laboratory owners and directors rely on modern LIS software to manage operations efficiently. Without a unified laboratory information system (LIS), your lab loses time to manual entry, disconnected billing systems, compliance risks, and operational bottlenecks. A robust LIS solution eliminates these challenges.
- Fragmented LIS modules forcing manual order entry and transcription errors
- Lab analyzer results that don't auto-upload into your main LIS platform
- Separate billing systems causing revenue cycle delays outside core LIS
- QC reporting managed manually, disconnected from your LIS system
- Providers waiting days for results via fax instead of integrated LIS delivery
- No real-time visibility into TAT, AR metrics, or operational LIS analytics
Prolis LIS Solution
Best LIS Software System for Total Lab Control
Prolis is not just another lab software. It is a complete Laboratory Information System (LIS) engineered to eliminate every bottleneck between your first specimen order and your final payment collected.
Built since 2009 by American Soft Solutions Corp., Prolis combines a powerful core LIS platform with Prolis Bridge an advanced integration hub that connects LIS to EMRs, lab analyzers, provider portals, and billing clearinghouses.
Prolis LIS configures tests at the analyte level not the module level supporting every clinical specialty (chemistry, toxicology, molecular, pathology, and more) without expensive fragmented LIS modules or costly add-ons.
Best LIS Software for Clinical Laboratories — Prolis Laboratory Information System is designed for lab owners, lab directors & lab managers who demand speed, accuracy, and end-to-end compliance in one integrated LIS platform.
Lab Ecosystem Integration Hub
A Complete Laboratory Ecosystem Platform
Prolis Bridge is the integration hub at the core of the platform enabling seamless, bi-directional communication between your internal lab operations and external healthcare networks.
EMRs & EHRs Connected to LIS
HL7 Integration
Provider Portal LIS Module
Web Orders & Secure Results
Prolis
Bridge
Integration HubLab Analyzers Connected
Bi-directional Interfaces
Core LIS Software Platform
Centralized Lab Operations
Complete LIS Workflow
Prolis Laboratory Information System Lifecycle:
Prolis Laboratory Information System Lifecycle:
Precision From Order to Payment
Every phase of your laboratory workflow pre-analytical, analytical, post-analytical, and revenue is managed seamlessly inside one intelligent LIS software.
1
Pre-Analytical Phase
Order Accession
Laboratory orders flow into your LIS software from EMRs via HL7 integration or the Provider Portal LIS module. Each specimen receives a unique accession ID, barcode label, and is routed automatically within your LIS system without manual intervention.
2
Analytical Phase
Analyzer Results
Prolis LIS software connects directly to your lab analyzers via Prolis Bridge. Results are captured in real time, auto-uploaded into your LIS, verified against QC rules, and reviewed with built-in delta checks within your laboratory information system before release.
3
Post-Analytical Phase
Report Generation
Verified results compile within your LIS software into fully customizable, audit-ready clinical and operational reports automatically formatted to your specifications and delivered via EMR or secure Provider Portal within your laboratory information system.
4
Revenue Cycle
Billing Management
The Billing Scrubber module within your LIS software prepares clean claims directly. Your LIS generates 837 files, routes through the clearing house, processes ERA 835 remittance, and posts payments — all within your laboratory information system without leaving the platform.
LIS Software Core Modules
Four Pillars of the Laboratory Information System
Prolis LIS software platform comprises four primary modules designed to handle every critical aspect of the modern laboratory workflow. Use the interactive tabs below to explore each core LIS module.
Core LIS Software Module
Highly Configurable
Configures laboratory tests at the analyte level, supporting chemistry, toxicology, microbiology, pathology, and molecular testing natively within one platform.
Order Management
Streamline accessioning and queue management within your LIS to prevent operational bottlenecks and ensure specimens flow efficiently through your laboratory information system.
Resulting Workflow
Automated workflows for result verification, release, and delta checks ensure quality and compliance at every step.
QC Management & Reporting
Built-in Levy-Jennings charts, audit trails, and customizable reporting engines within your LIS provide complete quality control and compliance documentation.
Prolis Bridge Integration Module
Analyzer Interfacing
Robust, bi-directional communication between your LIS and a vast library of lab instruments ensures seamless analyzer integration within your laboratory information system.
EMR Integration
Seamless data exchange utilizing HL7/FHIR standards enables to connect with external healthcare networks and major EHR platforms.
RCM & Clearing House Integration
Built-in billing scrubber, claims generation, ERA processing, and eligibility checks manage the complete revenue cycle within your laboratory information system.
State Reporting
Automated compliance and public health data transmission ensures regulatory reporting is accurate and timely.
Provider Portal Module
Web Orders
Clean, intuitive order entry allows physicians and clinics to submit laboratory tests electronically directly to your LIS.
Results Access
Real-time access to patient results with secure PDF generation and downloading capabilities.
Provider Communication
Instant alerts, panic value management, and direct communication keep providers informed and improve clinical workflows.
White-Labeled Portal
Branded experience options reflect your laboratory's unique identity and strengthen client relationships through your laboratory information system.
Patient Portal Module
Secure Access
Strictly HIPAA-compliant login protocols ensure patient data privacy and peace of mind.
Result Notifications
Automated system alerts sent directly to patients when their test results are finalized.
Patient Engagement
Empower patients to take control of their health data reducing inbound calls to the lab and improving patient satisfaction.
Complete LIS Software Features
Everything a Modern Laboratory Needs — Built In
Unlike modular, fragmented LIS solutions that charge for every add-on feature, Prolis LIS software delivers a complete laboratory information system feature set across your entire lab operation right out of the box.
Order Management & Accessioning
Streamline order intake from EMRs, Provider Portal, or manual entry within your LIS software. Automate barcode label generation, department routing, and accession queues within your laboratory information system, eliminating pre-analytical errors at the source.
Analyzer Interface & QC
Bidirectional analyzer connectivity through Prolis Bridge enables real-time result upload, automated QC checks, delta checks, and result verification so nothing gets released without passing LIS quality standards.
Clinical & Operational Reporting
Generate clinical reports, Levey-Jennings QC charts, TAT monitoring, audit trails, and operational dashboards all formatted to your specifications and auto-delivered. Built for CLIA compliance from day one.
Integrated Lab Billing & Revenue Cycle
Prolis LIS manages the complete revenue cycle from eligibility verification and 837 claim generation to ERA 835 processing, denial management, payment posting, AR tracking, and invoicing.
Prolis Bridge Integration Hub
Prolis Bridge is the connective tissue ecosystem linking LIS to EMRs, lab analyzers, clearing houses, state reporting systems, and RCM platforms through a single, secure integration layer.
Provider & Patient Portals
Give providers a branded, secure web portal to submit orders and review results. Empower patients with a patient-facing portal featuring secure access, email notifications, downloadable results and direct engagement tools.
Multi-Specialty Laboratory Software
Supporting Every Clinical Specialty
Prolis LIS software is not siloed by department. Because it's configures tests at the analyte level, a single solution runs your entire test menu from routine chemistry to advanced molecular diagnostics.
Chemistry LIS
Hematology LIS
Microbiology LIS
Toxicology LIS
Molecular LIS
Immunology LIS
Coagulation LIS
Autoimmune LIS
Industries Served by Prolis
Professional LIS Software Built for Every Type of Laboratory
Whether you operate a solo physician office lab or a multi-site reference laboratory network, Prolis LIS scales to your operational needs without replacing your workflow it enhances it with a complete laboratory information system.
Physician Office Labs
A lightweight yet powerful LIS for in-office testing. Fast setup, simple workflows, and direct EMR connectivity for busy clinical settings.
Reference Laboratories
High-volume, multi-client reference labs rely on Prolis for scalable accession management, robust QC, multi-provider portals, and automated billing.
Clinical Laboratories
Hospital-affiliated and independent clinical labs gain a unified connecting every department from chemistry to microbiology in one laboratory information system platform.
Toxicology Laboratories
Purpose-built workflows for drug screening, confirmatory testing, and chain-of-custody documentation. Fully compliant and deeply configurable for pain management labs.
Pathology Laboratories
Prolis LIS supports pathology-specific workflows including specimen management, surgical pathology reporting, and result delivery to ordering providers and patients.
Molecular Laboratories
From PCR panels to NGS workflows and pharmacogenetics, Prolis handles molecular testing with the precision and flexibility complex genetic diagnostics demand.
Role-Based LIS Business Impact
See the Measurable Impact, By Role
Different lab stakeholders have different priorities when implementing LIS software. Select a role below to see the operational improvements and business value your laboratory information system delivers.
Lab Owners & Leadership
Maximize ROI & Revenue Cycle with LIS. Reduce denied claims and scale your laboratory information system without hidden costs.
Lab Directors & Technical Staff
Ensure Compliance with LIS. Strict QC, audit trails, and rules-based workflows within your laboratory information system for CLIA/HIPAA compliance.
Lab Managers & Operations
Automate Workflows with LIS. Eliminate manual entry, enable remote accessioning, and automate delta checks within your laboratory information system.
Representative Impact on Revenue Cycle with Prolis LIS (Owners)
Typical operational metrics: legacy disconnected systems vs. integrated Prolis LIS software environment.
Comprehensive Prolis LIS Feature Library
Search. Filter. Explore LIS Features.
Prolis LIS software encompasses dozens of specific operational tools and features. Search by feature name or filter by category to understand the true breadth of the complete laboratory information system.
Search Prolis LIS Software Capabilities
No LIS features found matching your search criteria.
Laboratory Leaders & LIS Reviews
Trusted by Lab Directors, Managers & IT Administrators
Laboratory and IT leaders across the country rely on Prolis to power their laboratory information system operations.
★★★★★
"We had complex requirements for integrating our existing medical machines with our LIS. Prolis didn't just provide LIS software they found solutions to get everything connected. The ability to manage everything from within one platform is unmatched."
Eric Martin T.IT Administrator | Hospital & Healthcare
★★★★★
"The transition from our old LIS to Prolis LIS software was exceptionally smooth. Unlike other companies that cash the check and leave you with a manual, the Prolis support team was with us daily during our LIS implementation. Even our clients compliment how simple the web portal."
Joanna P.Laboratory Technical Director
★★★★★
"Capturing billable lab samples is a flawless feature in Prolis LIS software. The integrated billing and collection functions have significantly reduced our manual errors and improved our turnaround time for insurance claims."
Marci R.Operations Manager
Why Choose Prolis LIS Software
What Sets Prolis Apart From Competitors?
The LIS market is full of outdated, modular laboratory information systems that charge per feature and require separate vendors for billing, reporting, and integration. Prolis was engineered from the ground up to be completely different.
Analyte-Level Configuration — Not Module-Level
Most LIS vendors sell a separate module for each specialty. Prolis configures every test at the analyte level meaning one complete laboratory information system runs Chemistry, Toxicology, Molecular, and more without extra cost or complexity.
Native Automation in Every Step
Auto-accession, auto-upload from analyzers, auto-generated reports, and automated claims within Prolis LIS software remove the manual steps that slow laboratories down and cause costly errors.
Built-In Compliance & Audit Readiness
CLIA and HIPAA compliance is not a bolt-on feature. Every workflow in Prolis is designed with audit trails, QC documentation, and result integrity built into the core of laboratory information system.
White-Glove Implementation & Support
Unlike competitors who hand you a manual, Prolis provides dedicated LIS implementation support, personalized training, and responsive ongoing assistance so your team is never left behind.
LIS Software FAQs
Have questions about implementing a LIS? Here are the answers that matter most to lab owners, directors, and managers evaluating the best LIS software solution.
What is a Laboratory Information System (LIS) and how does LIS software work?
A Laboratory Information System (LIS) is a healthcare software solution that manages the processing, storage, and reporting of patient data related to laboratory testing. Modern LIS software like Prolis handles everything from order intake and specimen accession to result reporting and revenue cycle management all within one integrated platform.
What makes Prolis the best LIS software compared to other laboratory information systems?
Prolis is a complete LIS that configures tests at the analyte level not by module meaning you get support without paying for fragmented add-ons. Prolis includes built-in billing, EMR integration, analyzer connectivity, provider portals, and QC management in one platform developed and continuously supported since 2009.
Which lab types does Prolis LIS software support?
Prolis is designed for clinical, reference, toxicology, pathology, molecular, and physician office laboratories. Whether you are a solo POL or a multi-site reference laboratory network, Prolis scales to your volume, specialty mix, and client structure.
Does Prolis integrate with EMR systems and EHR platforms?
Yes. Prolis LIS connects to major EMR and EHR platforms through its Prolis Bridge integration hub, supporting bidirectional HL7/FHIR messaging. Orders come in from EMRs automatically, and verified results are delivered back eliminating manual data entry at both ends of your LIS.
Is Prolis CLIA and HIPAA compliant?
Absolutely. Prolis is designed for CLIA-certified diagnostic laboratories and maintains HIPAA compliance throughout all workflows including audit trails, access controls, secure result delivery, and data encryption standards.
How long does it take to implement Prolis LIS software in laboratory?
Implementation timelines vary based on lab size, integrations, and test menu complexity. Prolis provides a dedicated LIS implementation team that works with you through setup, configuration, training, and go-live of your laboratory information system with ongoing support available post-launch.
Ready to Modernize Your Laboratory?
Join diagnostic laboratories across the country that trust Prolis to power their daily operations from first specimen accession to final payment collected. Book your personalized demo and see the difference.
15+Years of LIS Innovation
8Clinical Specialties
1Unified LIS Software Solution
24/7Technical Support Available
Prolis Laboratory Information System (LIS) software is intended for use in CLIA-certified diagnostic laboratory testing facilities within the United States (US) market.