How to Streamline Lab Billing with Prolis

Why Lab Billing Is More Complex Than It Seems

For most labs, billing isn’t just a back-office task. It’s a critical function that determines revenue, compliance, and long-term viability. Yet many laboratories still rely on fragmented workflows, spreadsheets, or third-party billing platforms that don’t talk to their LIS. The result? Errors, delays, rejected claims, and thousands of dollars lost in uncollected revenue.

A streamlined billing system is not about adding another layer. It’s about removing friction. And the best way to do that is by embedding billing directly into the lab’s operational system.

That’s exactly what Prolis delivers.

The Hidden Costs of Manual or Disconnected Billing

Labs using disjointed systems for LIS and billing often face issues like:

• Double data entry between LIS and billing software
• Claims submitted with incomplete or mismatched information
• Slow turnaround from service to invoice
• High rejection rates from payers
• Lack of visibility into outstanding receivables

Every one of these issues creates drag not just financially, but operationally. Staff spend more time fixing billing issues than focusing on what matters: serving patients, running tests, and optimizing lab performance.

What Streamlined Lab Billing Actually Looks Like

A well-structured lab billing process should:

• Automatically generate claims from verified orders
• Ensure alignment between clinical data and billing codes
• Reduce manual intervention across the revenue cycle
• Give labs real-time visibility into claim status and AR
• Improve compliance with payer-specific rules and audit requirements

This is where Prolis stands apart. It’s not a bolt-on billing module. It’s a lab-native system where billing and operations are built to work together.

How Prolis Simplifies the Lab Revenue Cycle

1. Integrated Order-to-Invoice Flow

With Prolis, the billing process begins as soon as an order is created. Each test performed in the LIS automatically generates billable events that flow into the billing module. This ensures data consistency across departments and eliminates costly transcription errors.

2. Automated Claim Generation

Once testing is completed and results are verified, Prolis generates claims using pre-defined payer logic. CPT codes, ICD-10 mapping, and billing modifiers are applied automatically based on the lab’s configuration and testing profiles.

Claims can be submitted electronically to clearinghouses or payers directly, without needing to export data or manually re-enter patient and test details.

3. Real-Time AR Tracking

Prolis provides built-in dashboards that allow your team to monitor outstanding claims, payments received, rejections, and resubmissions. You can track days in AR, payment timelines, and denial patterns in real time no external spreadsheets required.

4. Customizable Financial Reports

With over 50 built-in report formats and the option to build ad hoc reports using SQL queries, Prolis gives you deep visibility into lab revenue, performance by payer, write-offs, and collection trends. Whether you’re answering a CFO question or preparing for an audit, you have what you need.

5. Payer Rule Logic and Rejection Handling

Each payer has its own quirks. Prolis includes a customizable rules engine that checks claims before submission, flags potential rejections, and helps labs get it right the first time. Built-in alerts and workflows ensure fast follow-up and fewer write-offs.

Key Outcomes from Streamlining Billing

Labs that implement Prolis typically see:

• 30–50% reduction in claim rejections
• Significant drop in days sales outstanding (DSO)
• Faster payment cycles through automated claim delivery
• Improved staff efficiency with fewer manual corrections
• Stronger compliance posture through audit-ready documentation

In other words, billing becomes a function of your system not a daily firefight.

Prolis: Built for Compliance, Built to Scale

Whether your lab serves one physician office or hundreds of provider clients, Prolis is built to scale with you. The billing engine supports:

• Commercial and government payers
• Client and patient billing
• Reference lab charges
• Custom pricing models
• Automated remittance processing (ERA)
• HIPAA-compliant audit logs and access tracking

Because Prolis billing is part of the core system, there’s no disconnect between clinical operations and financial outcomes.

Revenue Follows Systems, Not Spreadsheets

You shouldn’t have to choose between accuracy, speed, and compliance in your billing process. With Prolis, you don’t. Our system turns billing into a strategic function one that is traceable, automated, and deeply connected to the work you already do.

Ready to streamline your lab’s revenue cycle? 👉 See how Prolis simplifies billing →